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GLUTATHIONE AND AGING

Aging is a part of life, but healthy aging requires optimal glutathione levels. Glutathione synthesis decreases significantly as we age: teenagers have the highest levels, while those over age 60 have the lowest. Interestingly, the elderly (and in particular those 100 and over) who are in the best health have the highest levels of glutathione, on par with young adults.

"With normal aging, total glutathione levels decrease, but the centenarians in this study showed levels similar to those of young adults."

GLUTATHIONE AND DENTAL HEALTH

As the master antioxidant, Glutathione is the most important redox regulator that controls inflammatory processes, including the inflammation that occurs in the mouth and around the teeth (the periodontium). Patients with periodontitis (gum infection) have lower antioxidant and reduced glutathione status. Proper oral hygiene is certainly important, but so too is supporting the internal glutathione system. The implications of dental health and its connection with a variety of conditions is far-reaching.

GLUTATHIONE AND INFLAMMATION

Oxidative stress and chronic inflammation go hand in hand. It is important to provide cells with the building blocks necessary for the adequate production of Glutathione.

- "Acute" (short term) inflammation is the body's protective reaction to things like infections, radiation, harmful chemicals, foreign particles, trauma, and stress. Acute inflammation is also involved in tissue repair.

- Inflammation that fails to regulate is called "chronic" (long term) inflammation and contributes to the development and progression of numerous diseases and conditions. Limiting chronic inflammation is essential.

- "Redox homeostasis" is a kind of molecular balance inside the cell between Reactive Oxygen Species (ROS) and antioxidants, with the master antioxidant Glutathione (GSH) playing a major role. Oxidative stress occurs when ROS become excessive and outnumber available antioxidant resources.

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ALZHEIMER'S DISEASE AND GLUTATHIONE

"Roughly twenty years before the first symptoms of Alzheimer’s disease appear, inflammatory changes in the brain can be seen, according to a new study. The findings of the researchers, who monitored several pathological changes in the brain, suggest that activation of astrocytes at an early stage can greatly influence the development of the disease."

What's the connection? Research already has shown that glutathione levels are decreased in Alzheimer's patients. Astrocytes are a type of brain cell that rely on glutathione to maintain healthy brain function; in fact, astrocytes "shuttle" glutathione to neurons, which suggests that neurons depend on astrocytes for antioxidant defense. This new research shows that astrocyte-related

GLUTATHIONE AND SLEEP

Beauty rest, anyone? When you sleep, *you're* out cold, but your brain is a busy busy bee. That first one, Brain Drain? He's referring to the glymphatic system, managed by glial cells. Glial cells and the neurons they protect rely heavily on glutathione not only for defense against excess reactive oxygen species, but also as the "soap" that binds to molecules that the brain wants to wash away. No wonder then, given this waste management system, that many people who boost their cells' ability to produce glutathione report better sleep- they sleep soundly, and some recall more vivid dreams.

Further Reading:

Scientists Discover Previously Unknown Cleansing System in Brain
https://www.urmc.rochester.edu/…/scientists-discover-previo…

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress
http://www.jneurosci.org/content/23/8/3394.full.pdf

Photo Credit: habilis virtual assistant

GLUTATHIONE AND THE EYE

Glutathione, the master antioxidant, is critical for the health of the eyes: it protects against chemical and oxidative stress, to which portions of the eye are particularly vulnerable. Maintaining adequate levels of glutathione in the lens nucleus is critical for protection from the effects of oxidative stress and also for lens transparency. In fact, research shows that where age-related cataracts are concerned, the harder the lens nucleus the less glutathione present. Glutathione also plays an important role in hydration. 

Unfortunately as we age, our glutathione levels decrease and our antioxidant defence systems are overwhelmed. This results in increased

GLUTATHIONE; THE SOLUTION TO INFERTILITY?

Glutathione has been referred to as the “master antioxidant” and though it’s arguably the most important antioxidant out there, very few doctors know about it. Glutathione is produced by our own bodies (neat!), and is made up of three amino acids. It contains a whopping amount of sulfur, the compound that gives it much of its power. Glutathione can also be recycled, meaning that your body can use it over and over again. It’s main function is to quench all sorts of damaging chemicals that regularly float about in our bodies from inflammation and toxins. Each and every cell in our

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