GLUTATHIONE AND INFLAMMATION

Oxidative stress and chronic inflammation go hand in hand. It is important to provide cells with the building blocks necessary for the adequate production of Glutathione.

- "Acute" (short term) inflammation is the body's protective reaction to things like infections, radiation, harmful chemicals, foreign particles, trauma, and stress. Acute inflammation is also involved in tissue repair.

- Inflammation that fails to regulate is called "chronic" (long term) inflammation and contributes to the development and progression of numerous diseases and conditions. Limiting chronic inflammation is essential.

- "Redox homeostasis" is a kind of molecular balance inside the cell between Reactive Oxygen Species (ROS) and antioxidants, with the master antioxidant Glutathione (GSH) playing a major role. Oxidative stress occurs when ROS become excessive and outnumber available antioxidant resources.

-----------------------------------

"Investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis [MS, Parkinson’s disease, autism, depression, bipolar disorder, major depression, schizophrenia, chronic fatigue syndrome]. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of Glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines."

Further Reading-----------------------------------

Management of Inflammation Using Cellular Redox Modifiers
http://link.springer.com/chapt…/10.1007/978-81-322-2035-0_21

Redox homeostasis and cellular stress response in aging and neurodegeneration.
http://www.ncbi.nlm.nih.gov/pubmed/20013185

Glutathione homeostasis and redox-regulation by sulfhydryl groups
http://link.springer.com/article/10.1007/s11120-005-8425-1

Chronic inflammation and oxidative stress in human carcinogenesis
http://onlinelibrary.wiley.com/doi/10.1002/ijc.23192/full

Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches
http://www.sciencedirect.com/…/article/pii/S089158490000215X

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione
http://www.sciencedirect.com/…/article/pii/S0098299708000526

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
http://www.nature.com/tp/journal/v2/n7/abs/tp201261a.html

Glutathione Metabolism and Its Implications for Health
http://jn.nutrition.org/content/134/3/489.short

Problems with glutathione, oxidative stress, and runaway inflammation are seen in a host of diseases and conditions:
April 1, 2015: British Journal of Medicine
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders [Free Full Text]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382850/

Source: The glutathione connection