GLUTATHIONE; THE SOLUTION TO INFERTILITY?

Glutathione has been referred to as the “master antioxidant” and though it’s arguably the most important antioxidant out there, very few doctors know about it. Glutathione is produced by our own bodies (neat!), and is made up of three amino acids. It contains a whopping amount of sulfur, the compound that gives it much of its power. Glutathione can also be recycled, meaning that your body can use it over and over again. It’s main function is to quench all sorts of damaging chemicals that regularly float about in our bodies from inflammation and toxins. Each and every cell in our

bodies need and use glutathione, and when it’s deficient, our health will suffer.

Glutathione and Fertility

Glutathione is important for both male and female fertility. It can improve sperm health and quality. When it comes to the women’s ovaries, glutathione has an important role to play. Our eggs develop slowly and gradually in a process known as folliculogenesis over a period of many months before ovulation occurs. During this process, the many cells surrounding the egg, known collectively as the follicle, replicate. Each one of these tiny cells requires glutathione to shield it from damage. As such, the egg quality is dependent on glutathione – one of the ovary’s main protectors.

In fact, research has shown that oocytes with higher levels of intracellular glutathione produce healthier, stronger embryos. Other research has shown that in our younger years, women’s ovaries actually have higher intracellular glutathione levels. As such, increasing our glutathione can potentially turn back the ovarian “clock”. Research has shown that glutathione deficiency is related to premature ovarian aging and even ovarian cancer. Another study found that for women undergoing IVF, higher levels of glutathione in a woman’s follicles translated into increased fertilization rates.

 Glutathione and PCOS (Polycystic Ovarian Syndrome)

For women with PCOS, glutathione is also exceptionally important. A recent study challenged a group of 36 lean women with PCOS with a load of glucose. As would be expected, the women produced higher levels of insulin and testosterone in response to the dose of sugar. The study concluded that the glucose caused a significant increase in the oxidative stress markers, lowering the glutathione levels – and that this reduction in glutathione was associated with an increase in testosterone.

Another study that set out to evaluate DNA damage in the ovaries of women with PCOS concluded that there may be significantly less glutathione in the ovary as a result of the condition. As many women with PCOS have been when trying to conceive, egg quality is a key issue. Even for those women with PCOS who ovulate regularly, the time to conceive can be long – most often related to the quality of her follicles.

Another interesting study showing that after 6 weeks of treatment with N-acetyl cysteine, metformin and placebo, it was only the embryos from the NAC treated group that showed an increased number of good embryos on day 3 (after retrieval). Improved composition and overall ovarian cell health was significantly improved ONLY in the NAC-treated group.

Glutathione is protective for the egg quality of women with PCOS and increasing these levels can not only improve the chances of conceiving but also can increase the general rate of ovulation.

So, how do I increase my Gluathione?

1.     As glutathione is a sulfur-rich compound, eating sulfur rich foods like onions, garlic, brocolli, kale, cabbage and bok choy will help increase your glutathione levels.

2.     N-Acetyl Cysteine is one of my favourite supplements for increasing intracellular glutathione. It’s anti-inflammatory, and is protective to the cells in our bodies.

3.     Alpha Lipoic Acid is a great promoter of intracellular glutathione. It’s also wonderful for helping with blood sugar control and as such can be a great nutrient for women with PCOS.

4.     Selenium is a key mineral involved in the production of glutathione within our cells. Brazil nuts can be a great source of selenium, or alternately, organic forms of the supplement are best such as selenomethionine.

5.  The master of them all, CELLGEVITY which contains max proprietary science RIBOCEINE and increase glutathione 300% more than the next best alternative. it also contains Alpha lipoic acid, Selenomethionine, broccoli seed extract, resveratrol, Vit C etc.

MY NOTE:

Clomiphene and other known treatments for PCOS do not tackle the the root cause of  the problem but act to promote ovulation and sometimes temporarily restores menstruation. However, it should be known that one can have polycystic ovarian syndrome without scan evidence of cysts in the ovary, without issues with menses, without the other known physical symptoms of PCOS like hirsutism, Acne etc, but the biochemical defects  like, insulin, resistance, high estrogen and testosterone levels, high LH levels and low FSH levels will still be there. And in the long run this may lead to endometrial and breast cancers.

The use of both clomiphene and glutathione has had very promising outcomes with a reduction in side effects of clomiphene, in other words , it is better to treat with clomiphene and glutathione rather than with clomiphene alone.

N-acetyl Cysteine has been shown to be a good source of  glutathione but there is a better alternative which has been scientifically shown to be 300% more effective in raising glutathione and it contains 12 other ingredients that help raise glutathione level. 

This alternative is called CELLGEVITY!

CELLGEVITY has shown a lot of promise in solving the problem of infertility including PCOS with very many Testimonies too.

Testimonies: 

Pcos: From one of our doctors in Abuja today...I am so excited. I got a call from A lady with PCOS that hasnt seen her period in 8 months and then it was so scanty but today her period started and it came in full force (her words). She is on her third bottle of cellgevity. Her husband is so excited.
My joy knows no bound!

Low Sperm Count: Goodpm max family, one of my gynae patients, who has not been able to conceive for 3 years, had some investigations done relating to infertility and everything was normal but her husband's sperm count was low. The husband was placed on cellgevity for three months and the wife was also on it for two months. Just this afternoon, the wife got a positive pregnancy test. she is about 5 weeks pregnant. I was so excited while my patient was overwhelmed with joy. We truly have a miracle in cellgevity.     Dr T 

CELLGEVITY is approved by NAFDAC, HEALTH CANADA, HALAL and BSCG and is available in the following countries: USA, Nigeria, Ghana, Malaysia, Philippines, Canada, Singapore, Costa Rica, New Zealand, El Salvador, Hong Kong, Colombia, and Ivory Coast.

If you are ready to take the CELLGEVITY 90 days challenge for infertility please

Contact Dr Felix 07063892629 call/whatsapp for enquiries

Source:

Cheraghi E, Mehranjani MS, Shariatzadeh MA, Esfahani MH, Ebrahimi Z. N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin. Reprod Fertil Dev. 2014 Nov 13.

Fulghesu, A. M., Ciampelli, M., Muzj, G., Belosi, C., Selvaggi, L., Ayala, G.F., and Lanzone, A. (2002). N-Acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 77, 1128–1135.

http://www.whitelotusclinic.ca/blog/dr-fiona-nd/glutathione-antioxidant-fertility-pcos/

http://www.wholefamilyhealth.ca/story-behind-pcos/