GLUTATHIONE AND AUTISM

Epigenetics has taught us that there is a special interplay between our DNA and our environment. Whereas analyzing DNA is relatively easy, pinpointing environmental factors is a challenge. One thing to bear in mind is that cells possess machinery intended to protect against harmful environmental factors, but in autism, it has been observed that this machinery may not be working optimally. GSH is significantly decreased in the brains of subjects with autism.

Why don’t we know what environmental factors cause autism?
https://spectrumnews.org/…/why-dont-we-know-what-environme…/
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Brain region-specific glutathione redox imbalance in autism.
http://www.ncbi.nlm.nih.gov/pubmed/22528835

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
http://ajcn.nutrition.org/content/80/6/1611.short

Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: alterations in the activities and protein expression of glutathione-related enzymes.
http://www.ncbi.nlm.nih.gov/pubmed/23892356

Effectiveness of methylcobalamin and folinic acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status.
http://www.ncbi.nlm.nih.gov/pubmed/24224089

Illustration by Julia Yellow

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